Complete Mounjaro Dosing Guide: From 2.5mg to 15mg
Comprehensive guide to Mounjaro dosing schedules, titration protocols, and what to expect at each dose level from 2.5mg starter dose to 15mg maximum.
Medical Team
January 6, 2026
Complete Mounjaro Dosing Guide: Understanding Your Titration Journey
Key Dosing Information
- Starting dose: 2.5mg once weekly for 4 weeks
- Maintenance dose range: 5mg to 15mg once weekly
- Dose increases: 2.5mg increments every 4 weeks minimum
- Maximum dose: 15mg once weekly
Understanding Mounjaro Dose Titration
Mounjaro (tirzepatide) uses a carefully designed dose escalation protocol to help your body adjust to the medication while minimizing side effects. This gradual approach is essential for tolerability and optimal results.
The 2.5mg Starting Phase (Weeks 1-4)
Every Mounjaro journey begins with the 2.5mg dose, regardless of your weight loss goals or previous GLP-1 experience. This initiation phase serves several important purposes:
- Allows your digestive system to adapt to slowed gastric emptying
- Establishes your injection routine and technique
- Identifies any initial sensitivities or reactions
- Begins the process of appetite regulation
During this phase, most patients experience mild appetite reduction and may lose 2-5 pounds. Some experience minimal side effects, while others may have temporary nausea or digestive changes.
The 5mg Dose (Weeks 5-8)
After completing 4 weeks on 2.5mg, most patients advance to 5mg. This is the first true therapeutic dose where significant appetite suppression typically begins:
- Noticeable reduction in hunger and food noise
- Improved blood sugar control for those with diabetes
- Average weight loss of 3-5 percent of body weight by week 8
- Possible return of mild GI symptoms as body adjusts
The 7.5mg Dose (Weeks 9-12)
The 7.5mg dose often represents a sweet spot for many patients, offering strong efficacy with manageable side effects:
- Substantial appetite suppression
- Consistent weekly weight loss of 1-2 pounds
- Improved energy and reduced food preoccupation
- Better glycemic control for diabetic patients
The 10mg Dose (Weeks 13-16)
Moving to 10mg provides enhanced effects for those who need additional support:
- Maximum appetite suppression for most patients
- Continued steady weight loss
- Potential plateau-breaking for those who stalled at lower doses
- Strong metabolic benefits
The 12.5mg and 15mg Maximum Doses
The highest doses are reserved for patients who need maximum effect and have tolerated lower doses well:
- 12.5mg: Bridge dose for those approaching maximum therapy
- 15mg: Maximum approved dose for weight management
- Strongest appetite suppression and metabolic effects
- Not everyone needs to reach these doses for success
When to Stay at Your Current Dose
You may not need to increase your dose if you are experiencing consistent weight loss of 1 percent or more per week, side effects are manageable but noticeable, appetite suppression is effective, and you are satisfied with your progress.
Missed Dose Protocol
If you miss your scheduled dose, take it as soon as you remember if within 4 days. If more than 4 days have passed, skip the missed dose and take your next dose on the regularly scheduled day. Never take two doses within 3 days of each other.
Important: Dose adjustments should only be made under medical supervision. This guide is for educational purposes and does not replace professional medical advice.
Medical Disclaimer
This article is for educational purposes only and should not be considered medical advice. Always consult with qualified healthcare professionals before making decisions about your health or treatment.